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eGFR (CKD-EPI 2021)
Estimated GFR using the 2021 CKD-EPI equation — race-free, most accurate for CKD staging
Nephrology
⚕️
Clinical reference only. Not a substitute for professional medical judgment. Verify all results against institutional protocols before clinical use.
Calculate
eGFR estimates may be less accurate in extremes of muscle mass, amputees, or acute kidney injury. Confirm with clinical context.
Formula
eGFR = 142 × min(Scr/κ, 1)^α × max(Scr/κ, 1)^−1.200 × 0.9938^Age × (1.012 if female) κ = 0.7 (female), 0.9 (male) | α = −0.241 (female), −0.302 (male)
ScrSerum creatinine (mg/dL)
AgeAge (years)
κSex-specific creatinine threshold (0.7 F / 0.9 M)
αSex-specific exponent (−0.241 F / −0.302 M)
When to Use
CKD staging, medication dose adjustment, pre-contrast imaging assessment, diabetic nephropathy monitoring.
Clinical Pearls
- •The 2021 CKD-EPI equation removed race as a variable — use this in all patients.
- •eGFR <60 for >3 months = CKD; stage G3a or higher warrants nephrology co-management.
- •Adjust medication doses (e.g. metformin, NSAIDs, contrast agents) based on eGFR.
- •In India, lower muscle mass may lead to lower creatinine and overestimated eGFR — interpret with clinical context.
Original Publication
Inker LA (2021). N Engl J Med.